Description

Eta Antagonist 1 is a high-purity, small molecule compound designed for advanced research and development. This product is a critical tool for investigating endothelin receptor pathways, which are significant targets in cardiovascular and pulmonary research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of novel therapeutics targeting endothelin receptors.
• Cardiovascular Disease Studies: Used in preclinical research to study hypertension, pulmonary arterial hypertension (PAH), heart failure, and related vascular pathologies.
• Biochemical Assay Development: Employed as a selective ligand in receptor binding assays, high-throughput screening (HTS), and functional cellular assays to characterize compound activity.
• Academic & Institutional Research: A vital reagent for fundamental biological research into the endothelin system, signal transduction, and cell proliferation mechanisms.
• Process Chemistry & Scale-up: Used as a starting material or intermediate in the synthetic route for developing candidate drugs during the optimization and scale-up phases.

Basic Information

Product Name	Eta Antagonist 1
CAS No.	161801-60-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Endothelin A Receptor Antagonist; ETA Antagonist; BQ-123 (structural analog, common research context); Endothelin-1 Antagonist; ETA Receptor Blocker; (R)-2-[(R)-2-[(S)-2-[[1-(Hexahydro-1H-azepinyl)]carbonyl]amino-4-methylpentanoyl]amino-3-[3-(1-methyl-1H-indol-3-yl)]propanoyl]amino-3-(2-pyridyl)propionic Acid (related IUPAC); Research Compound 161801-60-1
EINECS	Contact for details

Quality Control

Our Eta Antagonist 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling using advanced techniques like HPLC and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.