Description

1-Naphthalenylsulfonyl-Ile-Trp-Aldehyde is a specialized peptide aldehyde derivative that functions as a potent and selective protease inhibitor. This compound is critical for biochemical research and pharmaceutical development, particularly in the study of enzyme mechanisms and the design of therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on developing treatments for conditions involving proteolytic dysregulation.

Application

• Protease Inhibition Research: Serves as a key biochemical tool for studying the activity and inhibition of specific proteolytic enzymes, such as cathepsins.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic agents targeting diseases like cancer, osteoporosis, and inflammatory disorders.
• Biochemical Assay Development: Employed as a reference standard or active component in high-throughput screening (HTS) assays to identify new drug candidates.
• Mechanistic Studies: Facilitates detailed investigations into enzyme kinetics, binding affinities, and structure-activity relationships (SAR) in medicinal chemistry.
• Academic Research: A valuable reagent for universities and research institutes conducting fundamental studies in biochemistry, molecular biology, and chemical biology.

Basic Information

Product Name	1-Naphthalenylsulfonyl-Ile-Trp-Aldehyde
CAS No.	161709-56-4
Molecular Formula	C26H29N3O4S
Molecular Weight	479.59 g/mol
Synonyms	NSC 40148; 1-Naphthalenesulfonylisoleucyltryptophanal; Ns-Ile-Trp-H; 1-Ns-Ile-Trp-H; Naphthalene-1-sulfonyl-L-isoleucyl-L-tryptophanal; Protease Inhibitor 40148; L-Isoleucyl-N-[(1S)-1-formyl-2-(1H-indol-3-yl)ethyl]-N-[(1-naphthylsulfonyl]-; (S)-2-((S)-2-((Naphthalene-1-sulfonamido)methyl)pentanamido)-3-(1H-indol-3-yl)propanal
EINECS	Contact for details

Quality Control

Our 1-Naphthalenylsulfonyl-Ile-Trp-Aldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.