Description

2-Naphthylmethanesulfonyl Chloride is a specialized organic intermediate belonging to the sulfonyl chloride class, characterized by its reactive functional group. This compound is critical for introducing the 2-naphthylmethanesulfonyl moiety into target molecules, enabling precise chemical modifications in advanced synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly for creating sulfonamide-based therapeutics.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides by acting as a sulfonating agent.
• Peptide Chemistry: Serves as a reagent for sulfonylation reactions in peptide modification and protection/deprotection strategies.
• Material Science: Employed in the synthesis of specialty polymers and dyes where the naphthyl group imparts specific optical or structural properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study protein function and interaction.
• Cross-coupling Reactions: Acts as a substrate or reagent in palladium-catalyzed cross-coupling reactions to construct complex aromatic systems.

Basic Information

Product Name	2-Naphthylmethanesulfonyl Chloride
CAS No.	161448-78-8
Molecular Formula	C11H9ClO2S
Molecular Weight	240.70 g/mol
Synonyms	2-Naphthalenemethanesulfonyl chloride; (2-Naphthylmethyl)sulfonyl chloride; 2-(Chlorosulfonylmethyl)naphthalene; 2-Naphthylmethylsulfonyl chloride; NSC 405124; 1-(Chlorosulfonylmethyl)naphthalene; α-Naphthylmethanesulfonyl chloride; 2-Naphthylmethanesulfonic acid chloride
EINECS	Contact for details

Quality Control

Our 2-Naphthylmethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.