Description

Alpha,β-Methyleneguanosine 5'-Diphosphate Sodium Salt is a chemically modified nucleotide analog, specifically a methylene-bridged guanosine diphosphate derivative. This compound is a critical biochemical tool for studying and modulating GTPase and kinase signaling pathways in cellular research. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and diagnostic developers for enzyme inhibition studies, assay development, and as a precursor for synthesizing more complex nucleotide probes.

Application

• Enzyme Inhibition Studies: Acts as a potent inhibitor or substrate analog for GTP-binding proteins (G-proteins) and certain kinases.
• Biochemical Assay Development: Used as a key component in high-throughput screening (HTS) assays to identify novel therapeutic compounds.
• Signal Transduction Research: Essential for investigating nucleotide-dependent signaling cascades in cell biology and oncology research.
• Pharmaceutical R&D: Serves as a building block or intermediate in the synthesis of nucleotide-based drug candidates.
• Diagnostic Reagent Formulation: Employed in the development of specialized diagnostic kits for monitoring enzymatic activity.
• Academic Research: A valuable tool for mechanistic studies in university and institutional biochemistry laboratories.

Basic Information

Product Name	Alpha,β-Methyleneguanosine 5'-Diphosphate Sodium Salt
CAS No.	161308-39-0
Molecular Formula	C11H14N5O13P2Na2 (or similar hydrate form)
Molecular Weight	Contact for details
Synonyms	α,β-Methyleneguanosine 5'-diphosphate sodium salt; Methylene-GDP sodium salt; Guanylyl methylenediphosphonate sodium salt; α,β-CH2-GDP sodium salt; GMPPCP sodium salt (common abbreviation); Guanosine 5'-[α,β-methylene]triphosphate sodium salt (related form); Nucleotide P1,P2-di(adenosine-5')-α,β-methylenetriphosphate analog (descriptive); 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[[hydroxy([hydroxy([hydroxy(phosphonooxy)phosphoryl]oxy)phosphoryl]oxy)methyl]oxolan-2-yl]-2-methylidene-6,9-dihydro-3H-purin-6-one sodium salt
EINECS	Contact for details

Quality Control

Our Alpha,β-Methyleneguanosine 5'-Diphosphate Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and potency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 5.0%
Nucleotide Impurities (HPLC)	≤ 3.0% total
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.