Description

Indirubin-3'-Monoxime is a potent and selective small molecule inhibitor with significant biological activity. This compound is a key synthetic derivative of indirubin, offering enhanced stability and specificity for research and development applications. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Pharmaceutical Research & Development: Serves as a critical tool compound for studying cell cycle regulation, specifically as a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β).
• Oncology Studies: Investigated for its anti-proliferative and pro-apoptotic effects in various cancer cell lines, making it valuable for preclinical cancer research.
• Neurodegenerative Disease Research: Used in models of Alzheimer's disease and other tauopathies due to its GSK-3β inhibitory activity, which is implicated in tau protein phosphorylation.
• Inflammatory Pathway Analysis: Employed to modulate inflammatory signaling pathways, including STAT3, for research into autoimmune and chronic inflammatory conditions.
• Stem Cell Research: Applied in studies to control differentiation and proliferation of stem cells through targeted kinase inhibition.
• Chemical Biology & Proteomics: Acts as a selective pharmacological probe to elucidate the function of specific kinases in complex biological systems.

Basic Information

Product Name	Indirubin-3'-Monoxime
CAS No.	160807-49-8
Molecular Formula	C16H10N2O2
Molecular Weight	262.27 g/mol
Synonyms	Indirubin 3'-Monoxime; 3'-(Hydroxyimino)indirubin; 2,3'-Biindolinylidene-2',3-dione 3'-oxime; 6-(3'-Hydroxyimino-2-oxoindolin-3-ylidene)-1,3-dihydro-2H-indol-2-one; GSK-3β Inhibitor IX; CDK Inhibitor; Indirubin-3'-oxime; I3O
EINECS	Contact for details

Quality Control

Our Indirubin-3'-Monoxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Red to reddish-brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.