Description

2,4,5-Trimethylphenylmagnesium Bromide CAS NO 160727-03-7 is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to act as a versatile nucleophile, introducing the 2,4,5-trimethylphenyl group into target molecules with high precision. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) and novel drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis.
• Advanced Material Research: Employed in the production of functionalized aromatics for organic electronic materials and liquid crystals.
• Fine Chemical Production: Facilitates the synthesis of specialty chemicals, flavors, and fragrances requiring specific aryl group incorporation.
• Academic and R&D Laboratories: A fundamental reagent for methodological development and exploratory organic chemistry research.

Basic Information

Product Name	2,4,5-Trimethylphenylmagnesium Bromide
CAS No.	160727-03-7
Molecular Formula	C9H11BrMg
Molecular Weight	223.39 g/mol
Synonyms	2,4,5-Trimethylphenylmagnesium Bromide; (2,4,5-Trimethylphenyl)magnesium Bromide; 2,4,5-Trimethylbenzylmagnesium Bromide (common misnomer); Mesitylmagnesium Bromide (related isomer); Grignard Reagent (2,4,5-Trimethylphenyl); Bromo(2,4,5-trimethylphenyl)magnesium; TMPMgBr (abbreviation); 1-Bromo-2,4,5-trimethylbenzene magnesium derivative
EINECS	Contact for details

Quality Control

Every batch of 2,4,5-Trimethylphenylmagnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Our products undergo rigorous quality testing, including titration for Grignard concentration and analysis of key impurities, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Due to its highly volatile and hygroscopic nature, the container must be kept sealed and allowed to equilibrate to room temperature before opening to minimize moisture ingress and pressure changes.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR/NMR)	Conforms to structure
Solvent	Specified (Tetrahydrofuran, Diethyl ether, or Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.