Description

Tyrphostin Ag 1290 is a potent and selective inhibitor of the platelet-derived growth factor receptor (PDGFR) tyrosine kinase. This compound is a critical research tool for studying cellular signaling pathways, proliferation, and angiogenesis. It is primarily utilized by researchers and scientists in the fields of oncology, cardiovascular disease, and cell biology for target validation and mechanistic studies.

Application

• Biochemical Research: Selective inhibition of PDGFR-β tyrosine kinase activity in in vitro enzyme assays.
• Cellular Signaling Studies: Investigation of PDGF-mediated signal transduction pathways, cell proliferation, and migration.
• Angiogenesis Research: Tool compound for studying the role of PDGFR in blood vessel formation and tumor angiogenesis models.
• Oncology Research: Preclinical research to understand the role of PDGFR in various cancers and evaluate potential therapeutic targets.
• Fibrosis and Cardiovascular Research: Studying the involvement of PDGFR in conditions like atherosclerosis, restenosis, and organ fibrosis.
• Stem Cell Research: Used to modulate signaling environments in stem cell culture and differentiation studies.

Basic Information

Product Name	Tyrphostin Ag 1290
CAS No.	160391-70-8
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 1290; AG-1290; Tyrphostin AG 1290; 6,7-Dimethoxy-2-phenylquinazolin-4-amine; 6,7-Dimethoxy-2-phenyl-4-quinazolinamine; PDGFR Tyrosine Kinase Inhibitor AG 1290; PDGFR Inhibitor AG 1290
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 1290 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical documentation, including HPLC, NMR, and MS data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.