Description

(-)-Staurosporine CAS NO 160335-45-5 is a potent, cell-permeable alkaloid compound that acts as a broad-spectrum protein kinase inhibitor. Its primary value lies in its ability to induce apoptosis in a wide range of cell types, making it an indispensable tool for biochemical and pharmacological research. This high-purity compound is essential for researchers and scientists in the fields of oncology, neuroscience, and cell biology, particularly for studying signal transduction pathways and cancer cell mechanisms.

Application

• Biomedical Research: A critical tool for studying protein kinase inhibition, signal transduction cascades, and programmed cell death (apoptosis).
• Oncology & Cancer Research: Used to investigate tumor cell proliferation, survival pathways, and as a positive control in chemosensitivity assays.
• Neuroscience Studies: Applied in research on neurodegenerative diseases and neuronal cell death models.
• Cell Biology & Biochemistry: Serves as a standard inhibitor in enzymatic assays to characterize kinase activity and function.
• Pharmaceutical Development: Used in early-stage drug discovery for target validation and screening of anti-cancer compounds.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental life science research.

Basic Information

Item	Details
Product Name	(-)-Staurosporine
CAS No.	160335-45-5
Molecular Formula	C28H26N4O3
Molecular Weight	466.54 g/mol
Synonyms	Staurosporine; Antibiotic AM-2282; STS; NSC 623442; (-)-Staurosporin; 7-Hydroxystaurosporine; 8,13-Epoxy-1H,6H,12H-diimidazo[1',5':1,6]pyrano[3,4-b]pyrrolo[3,4-c]carbazole-1,7(2H)-dione, 2,3,10,11,12,13-hexahydro-10-hydroxy-9-methoxy-2-methyl-; Microbial alkaloid
EINECS	Contact for details

Quality Control

Our (-)-Staurosporine is produced under strict quality management protocols to ensure the highest standards of purity and consistency required for sensitive research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility (Test in DMSO)	Clear, colorless to yellow solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.