Description

5-(2,2,2-Trifluoro-Acetylamino)-Naphthalene-1-Sulfonyl Chloride is a high-purity, specialized organic intermediate featuring a reactive sulfonyl chloride group and a trifluoroacetyl-protected amine. This compound is critical for the synthesis of complex molecules where precise functional group manipulation is required. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Research: Used in creating novel herbicides and fungicides with enhanced activity and selectivity.
• Fluorescent Probe & Dye Synthesis: Serves as a precursor for developing naphthalene-based fluorescent tags and sensors for biochemical assays.
• Polymer & Material Science: Employed in the modification of polymers and surfaces to introduce specific sulfonamide functionalities.
• Peptide & Protein Conjugation: Acts as a coupling reagent for labeling peptides or modifying proteins via reaction with amino groups.
• Chemical Biology Tool: Useful in activity-based protein profiling (ABPP) and other chemoproteomic applications.

Basic Information

Product Name	5-(2,2,2-Trifluoro-Acetylamino)-Naphthalene-1-Sulfonyl Chloride
CAS No.	160206-27-9
Molecular Formula	C₁₂H₇F₃NO₃S
Molecular Weight	302.25 g/mol
Synonyms	1-Naphthalenesulfonyl chloride, 5-[(2,2,2-trifluoroacetyl)amino]-; 5-(Trifluoroacetamido)naphthalene-1-sulfonyl chloride; 5-Amino-1-naphthalenesulfonyl chloride, N-trifluoroacetyl-; N-(1-Sulfonylchloridonaphthalen-5-yl)-2,2,2-trifluoroacetamide; 5-(2,2,2-Trifluoroacetamido)-1-naphthalenesulfonyl chloride; TFANS-Cl; CAS 160206-27-9
EINECS	Contact for details

Quality Control

Every batch of 5-(2,2,2-Trifluoro-Acetylamino)-Naphthalene-1-Sulfonyl Chloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.