Description

10-Methyl Docetaxel is a semi-synthetic taxane derivative and a key pharmaceutical intermediate in the development of novel anticancer agents. This compound is valued for its role in creating potent analogs of docetaxel, offering potential improvements in efficacy, solubility, or resistance profiles. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation taxane-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) of taxane derivatives.
• Drug Discovery & Development: Employed in the research and development pipeline for novel anticancer drugs targeting tubulin polymerization.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Studies: Utilized in *in vitro* and *in vivo* models to evaluate the potency and pharmacokinetics of new taxane analogs.

Basic Information

Product Name	10-Methyl Docetaxel
CAS No.	160084-81-1
Molecular Formula	C44H57NO14
Molecular Weight	830.93 g/mol
Synonyms	10-Methyl Docetaxel; Docetaxel, 10-methyl-; (2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, 10-methyl-; 10-Methyltaxotere; 10-Methyl-Docetaxel
EINECS	Contact for details

Quality Control

Our 10-Methyl Docetaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.