Description

Ent-8-Iso Prostaglandin F2α is a synthetic enantiomer of a key isoprostane, a class of prostaglandin-like compounds formed non-enzymatically by free radical-induced peroxidation of arachidonic acid. This compound is of significant value as a high-purity analytical reference standard and a critical research tool in biomedical studies. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on oxidative stress, lipidomics, and inflammatory pathways.

Application

• Biomedical Research Standard: Serves as an authentic standard for the quantification and validation of 8-iso-PGF2α in biological samples via LC-MS/MS or ELISA.
• Oxidative Stress Biomarker Studies: Used in research to investigate the role of isoprostanes as reliable markers of lipid peroxidation and oxidative damage in vivo.
• Pharmacology & Drug Development: Employed in studies to understand the biological activity of isoprostanes and to screen potential therapeutic agents targeting oxidative stress-related diseases.
• Clinical Diagnostics: Acts as a critical calibrator in the development and quality control of diagnostic assays measuring oxidative stress biomarkers.
• Metabolic Pathway Analysis: Utilized in lipidomic research to elucidate the formation and metabolic fate of isoprostanes compared to enzymatically derived prostaglandins.

Basic Information

Product Name	Ent-8-Iso Prostaglandin F2α
CAS No.	159812-83-6
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	ent-8-iso-Prostaglandin F2α; (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid (enantiomer of 8-iso-PGF2α); 8-iso-PGF2α enantiomer; 15-F2t-IsoP ent-enantiomer; ent-15-F2t-IsoP; 8-epi-PGF2α enantiomer; (15S)-8-iso-Prostaglandin F2α
EINECS	Contact for details

Quality Control

Our Ent-8-Iso Prostaglandin F2α is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via MS and NMR, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, acetonitrile; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.