Description

1,3-Cyclopentanediol,4,5-Difluoro-,Monoacetate,[1R-(1-α-,3-α-,4-Bta-,5-Bta-)]-(9Ci) is a high-purity, stereochemically defined fluorinated cyclopentane derivative. This compound is a critical chiral building block and advanced intermediate for the synthesis of complex molecules, offering precise control over stereochemistry and molecular architecture. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in medicinal chemistry programs targeting enzyme inhibition and receptor modulation.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating novel, high-performance pesticides and herbicides with enhanced activity and selectivity.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials where the introduction of fluorine atoms can modify surface properties and stability.
• Asymmetric Catalysis Ligand Precursor: The defined stereocenters make it a valuable starting material for synthesizing chiral ligands used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists in methodology development and exploring new chemical spaces in fluoroorganic chemistry.

Basic Information

Product Name	1,3-Cyclopentanediol,4,5-Difluoro-,Monoacetate,[1R-(1-α-,3-α-,4-Bta-,5-Bta-)]-(9Ci)
CAS No.	159752-15-5
Molecular Formula	C7H10F2O3
Molecular Weight	180.15 g/mol
Synonyms	(1R,3R,4S,5S)-4,5-Difluoro-1,3-cyclopentanediol monoacetate; [1R-(1α,3α,4β,5β)]-4,5-Difluoro-1,3-cyclopentanediol monoacetate; (1R,3R,4S,5S)-4,5-Difluorocyclopentane-1,3-diol monoacetate; 4,5-Difluoro-1,3-cyclopentanediol monoacetate (stereoisomer); Fluorinated cyclopentanediol acetate; CAS 159752-15-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), with strict control over stereochemical purity and impurity profiles. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and specific impurities are available upon request. Our quality system supports development and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and fluoride ions; store separately from such materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.