Description

5-Bromo-2,4-Difluorotoluene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals who require reliable, high-quality raw materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in fluorinated compounds which often exhibit enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethyl and bromo substituents contribute to biological activity.
• Liquid Crystal Materials (LCs): Serves as a core building block for fluorinated liquid crystal molecules used in display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electro-optical materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings to form biaryl structures.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new reactions and properties of fluorinated aromatics.

Basic Information

Product Name	5-Bromo-2,4-Difluorotoluene
CAS No.	159277-47-1
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-Bromo-3,5-difluoro-4-methylbenzene; 2,4-Difluoro-5-bromotoluene; 4-Methyl-3,5-difluorobromobenzene; Toluene, 5-bromo-2,4-difluoro-; 5-Bromo-2,4-difluoro-1-methylbenzene; α,α,3,5-Tetrafluoro-4-bromotoluene (incorrect but sometimes listed); 3,5-Difluoro-4-methylbromobenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Difluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-25°C. The container should be kept tightly sealed in a dry environment to minimize moisture exposure and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.