Description

N9-Isopropyl-Olomoucine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), specifically CDK2 and CDK5. This compound is a crucial research tool for studying cell cycle regulation, neuronal function, and apoptosis pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology and neurodegenerative disease research. The high specificity of this inhibitor makes it invaluable for mechanistic studies and target validation in drug discovery programs.

Application

• Biochemical Research: A key reagent for in vitro studies of CDK2 and CDK5 kinase activity and inhibition mechanisms.
• Cell Biology: Used to induce cell cycle arrest, particularly at the G1/S phase, for investigating proliferation and differentiation.
• Neuroscience Research: Employed in models to study the role of CDK5 in neuronal development, synaptic plasticity, and neurodegenerative conditions.
• Oncology Research: Serves as a reference compound in screening assays for developing novel anti-cancer therapeutics targeting cell cycle proteins.
• Drug Discovery & Development: Used as a pharmacological tool for target validation and lead optimization in preclinical stages.
• Academic & Institutional Labs: Fundamental research into the molecular mechanisms of the cell cycle and signal transduction pathways.

Basic Information

Product Name	N9-Isopropyl-Olomoucine
CAS No.	158982-15-1
Molecular Formula	C16H21N5O2
Molecular Weight	315.37 g/mol
Synonyms	2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-isopropylpurine; 6-Benzylamino-2-[(2-hydroxyethyl)amino]-9-isopropylpurine; Olomoucine II; Isopropyl-olomoucine; CDK2/5 Inhibitor; Purvalanol B (Note: Purvalanol B is a closely related analog, often used synonymously in literature); 9-Isopropylolomoucine
EINECS	Contact for details

Quality Control

Our N9-Isopropyl-Olomoucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.