Description

2-Piperidinemethanol,4-Fluoro-5-Hydroxy-,[2S-(2Alpha,4Alpha,5Alpha)]-(9Ci) is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D and manufacturing sectors, particularly in the development of targeted therapeutics where specific stereochemistry and fluorine substitution are required for optimal biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorinated, hydroxylated piperidine motifs on drug potency and pharmacokinetics.
• API Development: Integral to the multi-step synthesis of complex final active pharmaceutical ingredients requiring high stereochemical purity.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme mechanisms and receptor interactions.

Basic Information

Product Name	2-Piperidinemethanol,4-Fluoro-5-Hydroxy-,[2S-(2Alpha,4Alpha,5Alpha)]-(9Ci)
CAS No.	158955-60-3
Molecular Formula	C6H12FNO2
Molecular Weight	149.16 g/mol
Synonyms	(2S,4R,5R)-4-Fluoro-5-hydroxypiperidin-2-ylmethanol; (2S,4R,5R)-4-Fluoro-5-hydroxy-2-piperidinemethanol; 4-Fluoro-5-hydroxy-2-piperidinemethanol (stereoisomer); (2α,4α,5α)-4-Fluoro-5-hydroxy-2-piperidinemethanol; Fluorinated Hydroxy Piperidine Methanol Derivative; Chiral Fluoropiperidinol
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ state-of-the-art analytical techniques including HPLC, GC, NMR, and chiral analysis to guarantee identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.