Description

10-o-2,2-Dichloroethoxycarbonyl Docetaxel is a key synthetic intermediate in the production of the potent anticancer drug Docetaxel. This compound is critical for pharmaceutical manufacturers seeking to ensure the purity, efficacy, and regulatory compliance of their final active pharmaceutical ingredient (API). It is primarily required by advanced pharmaceutical R&D laboratories and API production facilities engaged in oncology drug development and manufacturing.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of the chemotherapeutic agent Docetaxel.
• Oncology Drug Development: Used in research and process development for novel taxane-based anticancer therapies.
• API (Active Pharmaceutical Ingredient) Manufacturing: Serves as a building block in the commercial-scale GMP production of Docetaxel API.
• Process Chemistry & Optimization: Employed in route scouting and yield improvement studies for more efficient Docetaxel synthesis.
• Reference Standard: Can be utilized as an analytical standard for quality control and impurity profiling in Docetaxel batches.
• Academic & Contract Research: Supports investigative studies in medicinal chemistry and pharmacology within academic and CRO settings.

Basic Information

Product Name	10-o-2,2-Dichloroethoxycarbonyl Docetaxel
CAS No.	158810-73-2
Molecular Formula	C47H57Cl2NO16
Molecular Weight	963.86 g/mol
Synonyms	10-O-(2,2-Dichloroethoxycarbonyl)docetaxel; Docetaxel 10-O-(2,2-dichloroethoxycarbonate); Docetaxel 10-carbonate, 2,2-dichloroethyl ester; 10-Deacetylbaccatin III 10-(2,2-dichloroethoxycarbonate) 13-ester with (2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester; Docetaxel Impurity; Docetaxel Intermediate; Taxotere Intermediate
EINECS	Contact for details

Quality Control

Our 10-o-2,2-Dichloroethoxycarbonyl Docetaxel is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.