Description

2,11-Dihydroxytrimipramine is a key metabolite and an important intermediate in the synthesis and pharmacological study of the tricyclic antidepressant trimipramine. This compound matters for its critical role in pharmaceutical research and development, particularly in metabolism studies, impurity profiling, and the synthesis of reference standards. It is primarily needed by pharmaceutical R&D laboratories, analytical service providers, and manufacturers of active pharmaceutical ingredients (APIs) and high-purity chemical standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of trimipramine and its metabolites in drug substances and products.
• Metabolite Research: Essential for in-vitro and in-vivo metabolism studies to understand the pharmacokinetic and pharmacodynamic profile of trimipramine.
• Impurity Profiling: Serves as a known impurity standard in the development and validation of analytical methods (e.g., HPLC, LC-MS) to ensure drug purity and safety.
• Chemical Synthesis Intermediate: Utilized as a building block in the organic synthesis of trimipramine analogs and related tricyclic compounds for research purposes.
• Forensic and Clinical Toxicology: Employed as an analytical standard in forensic labs and hospitals for the accurate detection and quantification of trimipramine metabolites in biological samples.
• Regulatory Compliance Testing: Critical for conducting tests required by pharmacopoeias (USP, EP) to meet regulatory submission standards for drug approval.

Basic Information

Product Name	2,11-Dihydroxytrimipramine
CAS No.	158798-76-6
Molecular Formula	C20H26N2O2
Molecular Weight	326.44 g/mol
Synonyms	2,11-Dihydroxytrimipramine; 10,11-Dihydroxytrimipramine (common isomer designation); 5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-2,11-diol; Trimipramine metabolite; 2,11-Dihydroxy-5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
EINECS	Contact for details

Quality Control

Our 2,11-Dihydroxytrimipramine is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.