Description

Cyclin H is a key regulatory protein that plays a critical role in the cell cycle and transcription as part of the CDK-activating kinase (CAK) complex. This compound is essential for research focused on cellular division mechanisms, gene expression regulation, and the development of targeted therapeutic strategies. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in oncology, molecular biology, and drug discovery programs.

Application

• Biochemical Research: Fundamental studies on cell cycle control, checkpoint regulation, and transcription initiation.
• Drug Discovery & Development: Target protein for screening and validating novel inhibitors in oncology and other proliferative diseases.
• Diagnostic Assay Development: Component in kits and assays designed to study CAK complex activity and related signaling pathways.
• Academic & Pharmaceutical R&D: Used as a standard or reagent in laboratories investigating protein-protein interactions and kinase function.
• Proteomics & Signal Transduction Studies: Essential for mapping kinase networks and understanding transcriptional regulation.

Basic Information

Product Name	Cyclin H
CAS No.	158540-26-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclin-H; CCNH; Cyclin H1; p34; p37; MO15-associated protein; CDK-activating kinase assembly factor MAT1; CAK complex subunit
EINECS	Contact for details

Quality Control

Our Cyclin H is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and functional activity are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (SDS-PAGE)	> 90%
Biological Activity (Kinase Assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.