Description

Proteasome Inhibitor I (CAS NO 158442-41-2) is a potent, cell-permeable peptide aldehyde that selectively and reversibly inhibits the chymotrypsin-like activity of the 20S proteasome. This compound is a critical research tool for studying the ubiquitin-proteasome pathway, a fundamental regulatory system for protein degradation and turnover within cells. It is essential for researchers in pharmaceutical development, biochemistry, and molecular biology investigating disease mechanisms related to protein homeostasis, such as cancer, neurodegenerative disorders, and inflammation.

Application

• Biochemical Research: A standard tool for in vitro and cell-based studies to inhibit proteasome activity and investigate protein degradation pathways.
• Drug Discovery & Mechanism of Action Studies: Used to validate the proteasome as a therapeutic target and to study the effects of proteasome inhibition on cell cycle, apoptosis, and signaling cascades.
• Cancer Research: Employed to model the effects of proteasome inhibition on tumor cell proliferation and survival, supporting the development of novel oncology therapeutics.
• Neurodegenerative Disease Research: Applied in models of diseases like Alzheimer's and Parkinson's to understand the role of protein aggregation and clearance.
• Inflammation & Immunology Studies: Used to examine the role of the proteasome in NF-κB activation and cytokine regulation.
• Academic & Institutional Laboratories: A key reagent for fundamental research into cellular protein quality control and regulatory mechanisms.

Basic Information

Product Name	Proteasome Inhibitor I
CAS No.	158442-41-2
Molecular Formula	C₂₆H₄₁N₅O₇
Molecular Weight	535.63 g/mol
Synonyms	MG-132; Z-Leu-Leu-Leu-al; Carbobenzoxy-Leu-Leu-Leucinal; Z-LLL-CHO; N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[[(2S,3S)-3-methyl-1-oxo-1-[[(2S)-2-oxo-2-pyrrolidin-1-ylethyl]amino]pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-L-leucinamide; Calpain Inhibitor I; Proteasome Inhibitor MG132; Leupeptin analog
EINECS	Contact for details

Quality Control

Our Proteasome Inhibitor I is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for sensitive life science research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and reliability for your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.