Description

Irofulven is a potent, semi-synthetic derivative of the fungal sesquiterpene illudin S, designed for targeted biological activity. This compound matters for its unique mechanism of action, which involves forming cytotoxic DNA adducts and inducing apoptosis in specific cell types. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for advanced oncology research, drug discovery, and the development of novel therapeutic agents.

Application

• Oncology Research: A key investigational compound for studying novel mechanisms of apoptosis and DNA damage response in cancer cell lines.
• Drug Discovery & Development: Serves as a lead compound or a biochemical tool in the development of new anti-cancer therapeutics.
• Biochemical Research: Used to investigate cellular stress pathways, reactive oxygen species (ROS) generation, and mitochondrial function.
• Preclinical Studies: Employed in animal models to evaluate efficacy, pharmacokinetics, and toxicology profiles for potential cancer treatments.
• Mechanism of Action Studies: A valuable tool for elucidating the interactions between sesquiterpene derivatives and cellular macromolecules.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Irofulven
CAS No.	158440-71-2
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	6-Hydroxymethylacylfulvene; HMAF; MGI 114; NSC 683863; (1aR,4S,4aR,7R,7aR,7bS)-1a,4,7-Trihydroxy-7-(hydroxymethyl)-1,1,4a,7b-tetramethyl-1a,2,3,4,4a,5,6,7,7a,7b-decahydro-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-one
EINECS	Contact for details

Quality Control

Our Irofulven is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.