Description

L-745337 CAS NO 158205-05-1 is a potent and selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme. This compound is a critical research tool for investigating inflammatory pathways and the role of COX-2 in various disease models. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical research.

Application

• Pharmacological Research: Used as a selective COX-2 inhibitor to study inflammation, pain, and fever mechanisms in preclinical models.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-inflammatory and analgesic agents.
• Biochemical Assays: Employed in enzymatic assays to selectively inhibit COX-2 activity and study its interaction with other biological pathways.
• Academic Research: A key reagent for university and institutional labs exploring prostaglandin biology and related signaling cascades.
• Target Validation: Used to validate COX-2 as a therapeutic target in various oncological and neurological research contexts.

Basic Information

Product Name	L-745337
CAS No.	158205-05-1
Molecular Formula	C17H14F3NO3S
Molecular Weight	369.36 g/mol
Synonyms	L-745,337; 5-Methanesulfonamido-6-(2,4-difluorothiophenyl)-1-indanone; 6-(2,4-Difluorophenylthio)-5-methanesulfonamido-1-indanone; COX-2 Inhibitor L-745337; 5-(Methylsulfonyl)-6-(2,4-difluorophenylthio)-1-indanone; L745337; L 745337
EINECS	Contact for details

Quality Control

Our L-745337 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.