Description

4-(Trifluoromethyl)Nicotinic Acid is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a nicotinic acid scaffold and a trifluoromethyl group, imparts desirable physicochemical properties to target molecules, enhancing metabolic stability and lipophilicity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	4-(Trifluoromethyl)Nicotinic Acid
CAS No.	158063-66-2
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	4-(Trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-; Nicotinic acid, 4-(trifluoromethyl)-; 4-Trifluoromethylnicotinic acid; 4-CF3-Nicotinic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.