Description

4-(Trifluoromethyl)Nicotinamide is a high-value fluorinated nicotinamide derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the unique properties imparted by the trifluoromethyl group, which enhances metabolic stability and lipophilicity in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for novel herbicides and pesticides, leveraging the trifluoromethyl group for improved bioactivity.
• Material Science Research: Used in the synthesis of advanced organic materials and ligands for catalysis.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in metabolic pathway studies and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	4-(Trifluoromethyl)Nicotinamide
CAS No.	158062-71-6
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	4-(Trifluoromethyl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 4-(trifluoromethyl)-; Nicotinamide, 4-(trifluoromethyl)-; 4-Trifluoromethylnicotinamide; 4-Carbamoyl-α,α,α-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Nicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.