Description

Ifn-γ Antagonist, (Tyr121,Cys(Acm)122)-Ifn-γ Receptor (120-141) (Human) is a synthetic peptide antagonist designed to specifically target and inhibit the human interferon-gamma (IFN-γ) receptor. This compound is a critical research tool for studying the IFN-γ signaling pathway, which plays a central role in immune regulation, inflammation, and autoimmune diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in immunology, oncology, and inflammatory disease research to develop novel therapeutic strategies.

Application

• Immunological Research: Used as a specific antagonist to block IFN-γ receptor binding, enabling the study of downstream JAK-STAT signaling pathways and immune cell activation.
• Autoimmune Disease Models: Employed in preclinical research to investigate the role of IFN-γ in conditions like rheumatoid arthritis, multiple sclerosis, and lupus.
• Oncology Research: Applied to understand the tumor microenvironment and the dual role of IFN-γ in tumor immune surveillance and progression.
• Inflammatory Pathway Analysis: Serves as a key reagent in cell-based assays and animal models to dissect the contribution of IFN-γ to chronic inflammatory responses.
• Therapeutic Candidate Screening: Used as a reference standard or control compound in high-throughput screening campaigns to identify new immunomodulatory drugs.
• Biochemical Assay Development: Integral for developing and validating ELISA, SPR (Surface Plasmon Resonance), or other binding assays to measure IFN-γ/receptor interactions.

Basic Information

Product Name	Ifn-γ Antagonist, (Tyr121,Cys(Acm)122)-Ifn-γ Receptor (120-141) (Human)
CAS No.	158040-83-6
Molecular Formula	C₁₁₀H₁₆₈N₃₀O₃₄S₂
Molecular Weight	2587.8 g/mol
Synonyms	IFN-γ Receptor (120-141) (human), tyr121, cys(acm)122; Interferon-gamma Receptor Fragment (120-141); IFNGR1 (120-141); hIFNGR1 Peptide Antagonist; (Tyr121,Cys(Acm)122)-hIFNGR1 (120-141); IFN-γ Antagonist Peptide; Human IFN-γ Receptor Antagonist Fragment; CAS 158040-83-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of this peptide antagonist is characterized using advanced analytical techniques to guarantee identity, purity, and biological activity. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), molecular weight confirmation (MS), and peptide content.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.