Description

Ftase Inhibitor Iii CAS NO 158022-12-9 is a potent and selective small molecule inhibitor of farnesyltransferase (FTase), a key enzyme in the post-translational modification of proteins like Ras. This compound is critical for disrupting oncogenic signaling pathways in cancer research and drug discovery. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, signal transduction studies, and the development of novel anti-cancer therapeutics.

Application

• Oncology Research: A key tool for studying Ras-dependent tumorigenesis and validating FTase as a therapeutic target.
• Drug Discovery & Development: Used as a reference standard and lead compound in high-throughput screening and medicinal chemistry programs.
• Signal Transduction Studies: Employed to elucidate the role of protein farnesylation in cell proliferation, differentiation, and survival pathways.
• Biochemical Assays: Serves as a positive control in enzymatic assays to measure FTase inhibition and compound potency.
• Academic Research: Facilitates fundamental biological research into cancer mechanisms and protein prenylation.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate the efficacy of farnesyltransferase inhibition.

Basic Information

Product Name	Ftase Inhibitor Iii
CAS No.	158022-12-9
Molecular Formula	C27H30N4O4
Molecular Weight	474.56 g/mol
Synonyms	Farnesyltransferase Inhibitor III; FTI-277; FTI 277; (S)-6-[(2R,5R)-2,5-Dimethyl-1-piperazinyl]-4-[[4-(morpholin-4-yl)phenyl]amino]-3-pyridinecarbonitrile; L-744,832; L 744832; L744832; SCH-66336; SCH 66336; Lonafarnib
EINECS	Contact for details

Quality Control

Our Ftase Inhibitor III is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.