Description

2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,trans-(9Ci) is a high-value fluorinated heterocyclic building block, specifically a trans-configured methyl ester derivative. This compound is critical for its role in introducing the 4-fluoro-tetrahydropyran moiety into complex molecular architectures, a key structural feature in modern medicinal chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. The product is supplied under strict quality control to ensure batch-to-batch consistency for sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides where the fluorinated pyran structure enhances biological activity and stability.
• Chemical Research & Development: Serves as a versatile building block in academic and industrial labs for exploring new fluorination methodologies and heterocyclic chemistry.
• Material Science Precursor: Potential use in the synthesis of specialty monomers or ligands for advanced polymeric or catalytic systems.
• Process Chemistry: Employed in scale-up routes for the production of target molecules requiring this specific fluorinated stereochemistry.

Basic Information

Product Name	2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,trans-(9Ci)
CAS No.	157919-99-8
Molecular Formula	C7H9FO3
Molecular Weight	160.14 g/mol
Synonyms	trans-4-Fluorotetrahydro-2H-pyran-2-carboxylic acid methyl ester; Methyl trans-4-fluorotetrahydro-2H-pyran-2-carboxylate; 4-Fluoro-tetrahydro-pyran-2-carboxylic acid methyl ester, trans-; (2R,4S)- and (2S,4R)-4-Fluorotetrahydro-2H-pyran-2-carboxylic acid methyl ester; 4-Fluoro-tetrahydropyran-2-carboxylic acid methyl ester; Fluorinated THP ester; 157919-99-8
EINECS	Contact for details

Quality Control

Every batch of 2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,trans-(9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to confirm identity, purity, and isomeric composition, ensuring it meets the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), enantiomeric/excess, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to strong bases and fluorophilic reagents; store separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Trans Isomer Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.