Description

Dihydrochlamydocin is a potent, cell-permeable cyclic tetrapeptide and a highly specific inhibitor of histone deacetylases (HDACs). This compound is a valuable research-grade biochemical tool for investigating epigenetic regulation, chromatin remodeling, and gene expression in various cellular contexts. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neuroscience, and metabolic disease research. Dihydrochlamydocin CAS NO 157618-75-2 offers a critical mechanism of action for probing HDAC function and validating novel therapeutic targets.

Application

• Epigenetics Research: Used as a selective HDAC inhibitor to study histone acetylation dynamics and their role in gene silencing and activation.
• Cancer Biology Studies: Employed in in vitro and in vivo models to investigate the effects of HDAC inhibition on tumor cell proliferation, differentiation, and apoptosis.
• Neuroscientific Applications: Applied in research exploring the role of HDACs in neurodevelopment, neurodegenerative diseases, and synaptic plasticity.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) assays for discovering new HDAC modulators.
• Drug Discovery & Preclinical Research: A key pharmacological tool for target validation and for understanding structure-activity relationships (SAR) in medicinal chemistry programs focused on HDAC inhibitors.

Basic Information

Product Name	Dihydrochlamydocin
CAS No.	157618-75-2
Molecular Formula	C₂₉H₄₀N₆O₆
Molecular Weight	568.67 g/mol
Synonyms	Cyclo[(2S)-2-Amino-8-oxodecanoyl-L-tryptophyl-D-phenylalanyl-L-prolyl]; HC-Toxin analog; HDAC Inhibitor, Dihydrochlamydocin; Chlamydocin derivative; FR235222 analog; Apicidin analog; Cyclic tetrapeptide HDAC inhibitor; (2S)-2-Amino-8-oxodecanoyl-L-Trp-D-Phe-L-Pro cyclic (4→1)-lactam
EINECS	Contact for details

Quality Control

Our Dihydrochlamydocin is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and strength is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.