Description

n-Acetyl-Alanyl-Phenylalanyl Chloroethyl Ketone is a specialized synthetic peptide derivative designed as a potent and selective protease inhibitor. This compound is of significant interest in biochemical and pharmaceutical research for its ability to modulate specific enzymatic pathways. It is primarily utilized by researchers and developers in the fields of medicinal chemistry, proteomics, and drug discovery for investigating disease mechanisms and developing novel therapeutic agents.

Application

• Protease Inhibition Studies: Used as a key biochemical tool to study the activity and function of specific serine or cysteine proteases in vitro.
• Medicinal Chemistry & Drug Discovery: Serves as a lead compound or intermediate in the development of novel therapeutic agents targeting protease-related diseases.
• Biochemical Research: Employed in enzymatic assays and pathway analysis to understand cellular processes and disease pathology.
• Pharmaceutical R&D: Utilized in preclinical research for evaluating pharmacokinetics, pharmacodynamics, and mechanism of action of potential drugs.
• Academic Research: A critical reagent for universities and research institutes focusing on enzymology, structural biology, and signal transduction.

Basic Information

Product Name	n-Acetyl-Alanyl-Phenylalanyl Chloroethyl Ketone
CAS No.	157239-64-0
Molecular Formula	C18H24ClN3O5
Molecular Weight	397.85 g/mol
Synonyms	Ac-Ala-Phe-CH2Cl; N-Acetyl-Ala-Phe-chloromethyl ketone; Acetylalanylphenylalanyl chloromethyl ketone; Protease Inhibitor Ac-Ala-Phe-CMK; Chloromethyl ketone inhibitor of proteases; AAPCK; N-Acetyl-L-alanyl-L-phenylalanyl chloromethyl ketone; Ac-Ala-Phe-CMK
EINECS	Contact for details

Quality Control

Our n-Acetyl-Alanyl-Phenylalanyl Chloroethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.