Description

6,3'-p-Dihydroxypaclitaxel is a key derivative of the potent anticancer agent paclitaxel, distinguished by its specific hydroxylation pattern. This compound is of significant interest in pharmaceutical research and development for its potential role in creating novel, more effective, or less toxic chemotherapeutic agents. It serves as a critical intermediate and reference standard for researchers and manufacturers in the oncology drug discovery and fine chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the semi-synthesis of novel paclitaxel analogs and next-generation taxane-based chemotherapeutics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) testing of paclitaxel and related compounds.
• Biochemical Research: Employed in studies investigating structure-activity relationships (SAR) of taxanes to understand the impact of hydroxyl group modifications on biological activity.
• Anticancer Agent Development: Acts as a precursor or lead compound in the research and development of new oncology drugs targeting tubulin polymerization.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic studies of paclitaxel to identify and quantify its derivatives in biological systems.

Basic Information

Product Name	6,3'-p-Dihydroxypaclitaxel
CAS No.	157230-10-9
Molecular Formula	C47H51NO16
Molecular Weight	885.91 g/mol
Synonyms	6α,3'-p-Dihydroxypaclitaxel; 6α-Hydroxy-3'-p-hydroxypaclitaxel; Paclitaxel, 6α,3'-p-dihydroxy-; 6α,3'-p-Dihydroxy Taxol; 2α,4α,5β,7β,10β,13α-Hexahydroxy-4,10-diacetoxy-11-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]taxa-1,11-dien-9-one 2,7,10-tris(2-methylbutanoate) 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
EINECS	Contact for details

Quality Control

Our 6,3'-p-Dihydroxypaclitaxel is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.