Description

8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed as a potent and selective antagonist of cAMP-dependent protein kinase (PKA). This compound is critical for researchers investigating intracellular signaling pathways, as it allows for the specific inhibition of PKA activity without affecting other cyclic nucleotide-regulated enzymes. It is an essential biochemical tool for pharmaceutical R&D, academic research in cell biology and neuroscience, and the development of therapeutic strategies targeting PKA-mediated disorders.

Application

• Biochemical Research: Used as a selective inhibitor of Protein Kinase A (PKA) to study cAMP-mediated signal transduction pathways.
• Pharmaceutical Development: Serves as a key reference standard and pharmacological tool in drug discovery programs targeting PKA-related diseases, such as cardiac disorders, cancer, and metabolic syndromes.
• Cell Biology Studies: Applied in cell culture experiments to elucidate the role of PKA in processes like gene expression, metabolism, and ion channel regulation.
• Neuroscience Research: Utilized to investigate PKA's function in neuronal plasticity, memory formation, and neurotransmitter release.
• Enzyme Kinetics: Employed in in vitro assays to determine the potency and specificity of novel PKA inhibitors.
• Diagnostic Reagent Manufacturing: May be used in the formulation of specialized kits for research and clinical diagnostics.

Basic Information

Product Name	8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	156816-36-3
Molecular Formula	C15H21N6O5PS1Na1
Molecular Weight	491.40 g/mol
Synonyms	Rp-8-PIP-cAMPS Sodium Salt; Rp-8-(4-Piperidino)adenosine-3',5'-cyclic monophosphorothioate Sodium Salt; Rp-8-Piperidino-cAMPS; cAMP antagonist Rp-isomer; Protein Kinase A Inhibitor (Rp-isomer); 8-PIP-cAMPS, Rp-; Adenosine, 8-(4-piperidinyl)-, cyclic 3',5'-(hydrogen phosphorothioate) Rp-isomer sodium salt
EINECS	Contact for details

Quality Control

Our 8-Piperidinoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for critical research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.