Description

Succinyl-Alanylalanyl-Prolyl-Phenylalanine Chloromethylketone is a synthetic peptide chloromethyl ketone derivative, functioning as a potent and irreversible inhibitor of serine proteases. This specificity makes it a critical tool for biochemical research and pharmaceutical development, enabling precise study and modulation of enzymatic pathways. It is primarily utilized by researchers and manufacturers in the fields of protease inhibitor development, peptide chemistry, and drug discovery.

Application

• Biochemical Research: As a specific active-site directed inhibitor for mechanistic studies of serine proteases like chymotrypsin and related enzymes.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of novel therapeutic protease inhibitors.
• Enzyme Characterization: Used to define the catalytic activity and specificity profiles of newly discovered proteases.
• Proteomics & Cell Biology: A tool for probing protease function in complex biological systems and signaling pathways.
• Quality Control: Acts as a reference compound in analytical methods for related pharmaceutical products.

Basic Information

Product Name	Succinyl-Alanylalanyl-Prolyl-Phenylalanine Chloromethylketone
CAS No.	156616-24-9
Molecular Formula	C30H38ClN5O7
Molecular Weight	616.10 g/mol
Synonyms	Suc-AAPF-CMK; Succinyl-Ala-Ala-Pro-Phe-chloromethyl ketone; AAPF-CMK; Chymotrypsin Inhibitor I, Suc-AAPF-CMK; Protease Inhibitor (Chymotrypsin); N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine chloromethyl ketone; Suc-AAPF-CH2Cl
EINECS	Contact for details

Quality Control

Our Succinyl-Alanylalanyl-Prolyl-Phenylalanine Chloromethylketone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.