Description

7-Iodobenzovesamicol is a high-purity, specialized organic compound of significant interest in neuropharmacological research. Its core value lies in its utility as a potent and selective ligand for the vesicular acetylcholine transporter (VAChT), a key target for studying cholinergic systems. This makes it an essential research chemical for scientists and pharmaceutical developers working on neurodegenerative diseases, such as Alzheimer's and Parkinson's. The compound, identified by CAS No. 156558-61-1, is supplied to meet the stringent demands of advanced biochemical and medicinal chemistry applications.

Application

• Neuropharmacological Research: Primary use as a selective radioligand for in vitro and ex vivo binding assays targeting the vesicular acetylcholine transporter (VAChT).
• PET Tracer Development: Serves as a precursor or reference standard in the synthesis and validation of potential positron emission tomography (PET) imaging agents for cholinergic neuron integrity.
• Biochemical Mechanism Studies: Used to investigate the function, density, and regulation of VAChT in synaptic vesicles within the central and peripheral nervous systems.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and evaluate novel compounds that modulate cholinergic neurotransmission.
• Reference Standard: Acts as a critical analytical standard in quality control and method development for related pharmaceutical compounds and research materials.
• Academic & Institutional Research: Fundamental tool for universities and research institutes studying cholinergic deficits associated with cognitive disorders and dementia.

Basic Information

Product Name	7-Iodobenzovesamicol
CAS No.	156558-61-1
Molecular Formula	C20H22INO
Molecular Weight	419.30 g/mol
Synonyms	(–)-7-Iodobenzovesamicol; (-)-7-IBVM; IBVM; (1R,2R,4S,5S)-7-Iodo-2-(4-phenylpiperidino)cycloheptanol; Vesamicol analog, 7-iodo-; Benzovesamicol, 7-iodo-; VAChT Ligand 7-Iodo
EINECS	Contact for details

Quality Control

Our 7-Iodobenzovesamicol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.