Description

2'-o-Methyl Paclitaxel is a semi-synthetic derivative of the potent anticancer agent paclitaxel, specifically modified at the 2'-hydroxyl position. This structural modification is designed to enhance metabolic stability and alter biological activity for advanced pharmaceutical research and development. It serves as a critical reference standard and intermediate for scientists in oncology research, medicinal chemistry, and the development of novel taxane-based therapeutics.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of taxane derivatives in research and quality control laboratories.
• Medicinal Chemistry Research: Acts as a key intermediate or precursor in the synthesis of novel paclitaxel analogs with potentially improved efficacy or reduced side effects.
• Oncology Drug Development: Employed in preclinical studies to investigate structure-activity relationships (SAR) and mechanisms of action against various cancer cell lines.
• Biochemical Research: Utilized in studies focusing on tubulin polymerization dynamics and microtubule stabilization, the primary mechanism of paclitaxel.
• Metabolism and Pharmacokinetics Studies: Serves as a model compound to study the metabolic pathways and stability of modified taxanes.

Basic Information

Product Name	2'-o-Methyl Paclitaxel
CAS No.	156413-67-1
Molecular Formula	C47H51NO14
Molecular Weight	853.91 g/mol
Synonyms	2'-O-Methylpaclitaxel; 2'-Methylpaclitaxel; Paclitaxel 2'-Methyl Ether; NSC 716088; (2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate 2'-Methyl Ether
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl Paclitaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.