Description

Manumycin F CAS NO 156317-47-4 is a potent and specific natural product inhibitor of farnesyltransferase, an enzyme critical in the Ras signaling pathway. This compound is a vital research tool for studying oncogenic processes, cellular signaling, and protein prenylation. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, target validation, and biochemical pathway analysis.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of farnesyltransferase and Ras protein function in signal transduction pathways.
• Oncology Research: A key tool for investigating cancer cell proliferation, apoptosis, and metastasis mechanisms driven by Ras mutations.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and the development of novel anti-cancer therapeutics.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in cell biology, microbiology, and enzymology.
• Pharmaceutical Intermediates: Can be used in the synthesis of more complex molecules or analogs for biological evaluation.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control of related compounds.

Basic Information

Product Name	Manumycin F
CAS No.	156317-47-4
Molecular Formula	C31H42N2O6
Molecular Weight	538.68 g/mol
Synonyms	Manumycin F; UCF1-C; Antibiotic UCF1-C; Farnesyltransferase inhibitor UCF1-C; (2E,4E,6E,8E)-10-[(2R,3S,5S,6R)-3,5-Dimethyl-6-[(1E,3E,5E)-6-methyl-7-(2-methyloxazol-4-yl)hepta-1,3,5-trien-1-yl]oxan-2-yl]-N-hydroxy-2,4,6,8-decatetraenamide; (2E,4E,6E,8E)-10-[(2R,3S,5S,6R)-3,5-Dimethyl-6-[(1E,3E,5E)-6-methyl-7-(2-methyl-1,3-oxazol-4-yl)hepta-1,3,5-trien-1-yl]tetrahydro-2H-pyran-2-yl]-N-hydroxy-2,4,6,8-decatetraenamide
EINECS	Contact for details

Quality Control

Our Manumycin F is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.