Description

Manumycin G is a potent and selective natural product inhibitor of farnesyltransferase, an enzyme critical in the Ras signaling pathway. This compound is a valuable research-grade biochemical for investigating oncogenic processes and developing targeted cancer therapeutics. It is essential for pharmaceutical R&D, academic research in cell biology, and biotechnology applications focused on signal transduction and drug discovery.

Application

• Biochemical Research: Used as a specific tool compound to inhibit farnesyltransferase and study the Ras protein signaling cascade in cellular and molecular biology experiments.
• Oncology Research: Investigated for its potential anti-cancer properties in preclinical studies targeting Ras-dependent tumor growth and proliferation.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for the design and synthesis of novel farnesyltransferase inhibitors.
• Cell Signaling Pathway Analysis: Employed to elucidate the role of protein prenylation in various cellular functions, including differentiation and apoptosis.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental research in cancer biology and enzymology.

Basic Information

Product Name	Manumycin G
CAS No.	156250-44-1
Molecular Formula	C31H38N2O7
Molecular Weight	550.65 g/mol
Synonyms	Manumycin G; Antibiotic UCF116-A; UCF 116-A; UCF-116A; (2E,4E,6E,8E)-10-[(3S,5S,6R)-5,6-Dihydroxy-3-methyl-2-oxo-1-cyclohexen-1-yl]-N-[2-hydroxy-5-(1-methylpropyl)phenyl]-2,4,6,8-decatetraenamide; (E,E,E,E)-UCF116-A
EINECS	Contact for details

Quality Control

Our Manumycin G is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.