Description

.Beta.-Cyclodextrin, 2-Hydroxy-3-(Trimethylammonio)Propyl Ethers, Chlorides is a chemically modified, permanently cationic derivative of β-cyclodextrin. This compound is engineered to enhance solubility and provide a permanent positive charge, making it a powerful complexation and delivery agent for anionic or hydrophobic molecules. It is primarily utilized in advanced pharmaceutical formulations, biotechnology, and specialty chemical synthesis where controlled molecular encapsulation and charge-based interactions are critical.

Application

• Pharmaceutical Solubilization & Delivery: Acts as a novel excipient to improve the aqueous solubility, stability, and bioavailability of poorly soluble or anionic active pharmaceutical ingredients (APIs).
• Gene & Nucleic Acid Delivery: Serves as a cationic complexing agent for non-viral gene delivery systems, facilitating the condensation and cellular uptake of DNA, siRNA, or mRNA.
• Analytical Chemistry & Separation Science: Used as a chiral selector or stationary phase modifier in capillary electrophoresis and chromatography for the separation of enantiomers and isomers.
• Cosmetic & Personal Care Formulations: Employed to stabilize and control the release of fragrances, vitamins, or active ingredients in creams and lotions.
• Catalyst & Reaction Media: Functions as a phase-transfer catalyst or a supramolecular reaction vessel in organic synthesis to enhance reaction rates and selectivity.
• Environmental Remediation: Applied in water treatment processes to complex and remove specific anionic contaminants, dyes, or heavy metals from industrial effluents.

Basic Information

Product Name	.Beta.-Cyclodextrin, 2-Hydroxy-3-(Trimethylammonio)Propyl Ethers, Chlorides
CAS No.	156228-03-4
Molecular Formula	C63H126Cl7N7O35 (Approx., degree of substitution dependent)
Molecular Weight	~1700 g/mol (Approx., degree of substitution dependent)
Synonyms	β-Cyclodextrin, 2-hydroxy-3-(trimethylammonio)propyl ether, chloride; Cationic β-Cyclodextrin; (2-Hydroxy-3-trimethylammoniopropyl)-β-cyclodextrin chloride; Quaternized β-Cyclodextrin; β-CD-TMA; TMABC; β-Cyclodextrin polymer with (chloromethyl)oxirane and N,N-dimethylmethanamine; 2-Hydroxy-3-(trimethylammonio)propyl-β-cyclodextrin chloride
EINECS	Contact for details

Quality Control

Our .Beta.-Cyclodextrin, 2-Hydroxy-3-(Trimethylammonio)Propyl Ethers, Chlorides is manufactured under a strict quality management system. Each batch is subjected to rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that detail key parameters such as degree of substitution, assay, residual solvents, and microbiological quality, supporting applications in GMP environments. Specifications can be aligned with customer-specific requirements for pharmaceutical or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). To prevent moisture uptake and decomposition, keep the container tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (NMR/Titration)	≥ 95.0%
Degree of Substitution (DS)	Customer specified (e.g., 3.0 - 7.0)
Water Content (KF)	≤ 10.0 %
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Microbiological Quality	Meets in-house specifications

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.