Description

3,9-Bis((Ethylthio)Methyl)-K-252A is a chemically modified derivative of the potent protein kinase inhibitor K-252a, designed to enhance specific physicochemical properties. This compound is of significant value in advanced biochemical and pharmacological research, particularly in the study of cell signaling pathways and neurotrophic activity. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutic agents and high-value research tools.

Application

• Biochemical Research: As a key tool compound for investigating protein kinase C (PKC) and other serine/threonine kinase signaling pathways in cellular models.
• Neurobiology Studies: Used in research focused on neurotrophin signaling, neuronal differentiation, and survival, leveraging its activity as a Trk receptor agonist.
• Pharmaceutical Development: Serves as a critical intermediate or reference standard in the discovery and development of new kinase-targeted therapeutics.
• High-Throughput Screening (HTS): Employed as a control or probe molecule in assay development and screening campaigns for identifying new kinase modulators.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, cancer research, and signal transduction mechanisms.

Basic Information

Product Name	3,9-Bis((Ethylthio)Methyl)-K-252A
CAS No.	156177-65-0
Molecular Formula	C27H27N5O3S2
Molecular Weight	533.66 g/mol
Synonyms	3,9-Bis(ethylthiomethyl)-K-252a; 7,12-Dihydro-indolo[3,2-d][1]benzazepine-6-carboxylic acid, 9-[(ethylthio)methyl]-3-[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester; K-252a derivative, ethylthio-methylated; 3,9-Bis(ethylsulfanylmethyl)-K-252A; (9S,10R,12R)-9,10-Dihydro-10-hydroxy-9-[(ethylthio)methyl]-3-[(ethylthio)methyl]-9-methyl-1-oxo-7H,8H,9H,10H,11H,12H-indolo[3,2-d][1]benzazepine-12-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3,9-Bis((Ethylthio)Methyl)-K-252A is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) containing all analytical data is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.