Description

Bq-788 CAS NO 156161-89-6 is a potent and selective endothelin B (ETB) receptor antagonist widely used in biochemical and pharmacological research. Its primary value lies in enabling precise investigation of endothelin signaling pathways, which are critical in cardiovascular physiology and disease. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors studying pulmonary arterial hypertension, cancer, and other conditions mediated by endothelin.

Application

• Pharmacological Research: A key tool for studying the role of ETB receptors in cardiovascular diseases, renal function, and cancer progression.
• Drug Discovery & Development: Used as a reference standard and screening agent in the development of novel endothelin receptor-targeted therapeutics.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays, and signal transduction pathway analysis.
• Academic & Institutional Research: Supports fundamental scientific studies in university and government laboratories exploring endothelin biology.
• In Vitro Diagnostics: May be utilized in the development of specialized diagnostic tests related to endothelin system dysregulation.

Basic Information

Item	Detail
Product Name	Bq-788
CAS No.	156161-89-6
Molecular Formula	C34H44N4O7S
Molecular Weight	652.81 g/mol
Synonyms	BQ-788; BQ 788; N-cis-2,6-Dimethylpiperidinocarbonyl-L-γ-methylleucyl-D-1-methoxycarbonyltryptophanyl-D-norleucine; IRL 2500; IRL-2500; Endothelin B Receptor Antagonist BQ-788; (2R)-2-[(2S)-2-[[(2S,6R)-2,6-Dimethylpiperidin-1-yl]carbonylamino]-4-methylpentanoyl]-N-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-1-oxohexan-2-yl]-4-methylpentanamide
EINECS	Contact for details

Quality Control

Our Bq-788 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.