Description

Alvimopan is a peripherally acting mu-opioid receptor antagonist (PAMORA) of significant pharmaceutical importance. Its primary value lies in its ability to accelerate the recovery of gastrointestinal function following bowel resection surgery without compromising centrally mediated opioid analgesia. This makes it a critical component in post-operative care protocols. It is specifically targeted at pharmaceutical manufacturers and research institutions developing or producing therapies for postoperative ileus (POI).

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of oral capsules used in hospital settings.
• Clinical Research for studying gastrointestinal motility disorders and opioid-induced bowel dysfunction.
• Formulation Development for creating novel drug delivery systems targeting peripheral opioid receptors.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Pharmacological Studies investigating the separation of central and peripheral opioid effects.

Basic Information

Product Name	Alvimopan
CAS No.	156053-89-3
Molecular Formula	C25H32N2O4•2H2O
Molecular Weight	460.56 g/mol (Dihydrate)
Synonyms	LY-246736; ADL 8-2698; (2S)-2-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]pentanamide dihydrate; Alvimopan Dihydrate; Entereg (Brand Name)
EINECS	Contact for details

Quality Control

Our Alvimopan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength in accordance with current industry standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for pharmaceutical use. We support our clients with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	6.0% - 9.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	-20.0° to -24.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.