Description

Clasto-Lactacystin β-Lactone is a potent and highly specific proteasome inhibitor, representing the active form of the natural product lactacystin. This compound is critical for disrupting the ubiquitin-proteasome pathway, a fundamental regulatory system for protein degradation within cells. It is an essential research tool for scientists in pharmacology, oncology, and molecular biology studying cellular processes, disease mechanisms, and novel therapeutic targets.

Application

• Biomedical Research: A key reagent for studying proteasome function, protein turnover, and the role of the ubiquitin-proteasome pathway in cellular regulation and signaling.
• Oncology Studies: Used to investigate cancer cell apoptosis, proliferation, and the development of proteasome inhibitors as potential chemotherapeutic agents.
• Neurodegenerative Disease Research: Applied in models of diseases like Alzheimer's and Parkinson's to understand the accumulation of misfolded proteins.
• Inflammation & Immunology: Utilized to explore the proteasome's role in NF-κB activation and the regulation of inflammatory responses.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for the design and screening of new proteasome-inhibiting pharmaceuticals.
• Biochemical Assays: Employed in enzymatic assays to specifically inhibit the chymotrypsin-like activity of the 20S proteasome core particle.

Basic Information

Product Name	Clasto-Lactacystin β-Lactone
CAS No.	155975-72-7
Molecular Formula	C15H24N2O7S
Molecular Weight	376.43 g/mol
Synonyms	Clasto-Lactacystin β-Lactone; (2S,3R)-3-Hydroxy-2-[(2S)-2-hydroxy-2-methyl-4-(methylsulfanyl)butanoyl]amino]-4-methylpentanoic acid β-lactone; Lactacystin β-Lactone; Omuralide; NSC 332500; Proteasome Inhibitor I; MG-132 analog (active form)
EINECS	Contact for details

Quality Control

Our Clasto-Lactacystin β-Lactone is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.