Description

1-Bromo-4-(2,2,2-trifluoroethyl)benzene is a high-value halogenated aromatic building block characterized by a benzene ring substituted with a bromine atom and a trifluoroethyl group. This compound matters for its role as a versatile intermediate in advanced organic synthesis, where the bromine atom serves as an excellent site for cross-coupling reactions and the trifluoroethyl moiety imparts unique physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as in materials science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoroethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorine-containing structure.
• Cross-Coupling Reactions: The bromine substituent makes it an ideal substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine introduction on molecular properties in medicinal and synthetic chemistry programs.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	1-Bromo-4-(2,2,2-trifluoroethyl)benzene
CAS No.	155820-88-5
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	4-Bromo-α,α,α-trifluoroethylbenzene; p-Bromobenzotrifluoroethane; (4-Bromophenyl)-2,2,2-trifluoroethane; 1-Bromo-4-(trifluoroethyl)benzene; 4'-Bromo-2,2,2-trifluoroethylbenzene; 2,2,2-Trifluoro-1-(4-bromophenyl)ethane; Benzene, 1-bromo-4-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(2,2,2-trifluoroethyl)benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.