Description

Okadaic Acid Potassium Salt is a highly specific and potent inhibitor of protein phosphatases PP1 and PP2A, making it an indispensable research tool in cell biology and signal transduction studies. Its primary value lies in its ability to induce hyperphosphorylation of cellular proteins, which is critical for investigating phosphorylation-dependent pathways, tumor promotion, and Alzheimer's disease pathology. This biochemical is essential for researchers and scientists in the pharmaceutical, biotechnology, and academic sectors who require high-purity, reliable reagents for mechanistic studies and assay development.

Application

• Biochemical Research: As a standard inhibitor for studying serine/threonine protein phosphatase activity in cell lysates and purified enzyme preparations.
• Signal Transduction Studies: To investigate phosphorylation cascades and the role of PP1/PP2A in cellular processes like metabolism, cell cycle progression, and apoptosis.
• Toxicology & Cancer Research: Used as a reference toxin to study diarrhetic shellfish poisoning (DSP) and to model tumor promotion mechanisms in vitro.
• Neuroscience Research: Applied in models to study tau protein hyperphosphorylation, a key event in neurodegenerative diseases such as Alzheimer's.
• Diagnostic Development: Serves as a critical component in the development and validation of ELISA and other immunoassays for detecting okadaic acid and related toxins in seafood.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) assays to identify novel phosphatase inhibitors or modulators for therapeutic development.

Basic Information

Product Name	Okadaic Acid Potassium Salt
CAS No.	155751-72-7
Molecular Formula	C44H65KO13
Molecular Weight	841.06 g/mol
Synonyms	Okadaic Acid K Salt; Potassium Okadaate; 1H-Benz[cd]indol-2-ol, 1,3,4,6,7,8,9,10,11,11a-decah-10-hydroxy-9-(hydroxymethyl)-2,6,8-trimethyl-9-[(2E,4S,6R,8S,10S,12S,13S,14E,16E,18S,19S)-6,8,19-trihydroxy-4,10,12,16-tetramethyl-15-oxo-3,20-dioxabicyclo[16.3.1]docosa-1(21),14,16,18-tetraen-18-yl]-4-methoxy-5-oxo-, potassium salt (1:1); OA-K; PP1/PP2A Inhibitor (Potassium Salt); DSP Toxin Standard (Potassium Salt)
EINECS	Contact for details

Quality Control

Our Okadaic Acid Potassium Salt is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and safety data. We support research and production needs that may require compliance with cGMP or other specific quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Potassium Content	Conforms to theoretical
Biological Activity (PP2A Inhibition IC50)	≤ 1.0 nM
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.