Description

Bistramide K is a potent marine-derived cyclic depsipeptide with significant biological activity. This compound is valued for its role as a selective modulator of voltage-gated sodium channels, making it a crucial tool in neurobiological and pharmacological research. It is primarily utilized by research institutions and pharmaceutical R&D departments for investigating ion channel function, developing novel therapeutics, and studying cellular signaling pathways.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of voltage-gated sodium channels (NaV channels) in neuronal cells.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the search for new analgesics, antiarrhythmics, and anticonvulsants targeting ion channels.
• Cellular & Molecular Biology: Used to investigate the role of specific sodium channel isoforms in cellular excitability, signal transduction, and disease models.
• High-Throughput Screening (HTS): Employed as a control or reference compound in assays designed to identify new modulators of ion channel activity.
• Biochemical Research: Utilized in binding studies and mechanistic investigations to understand ligand-receptor interactions at sodium channels.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical studies within universities, research institutes, and biopharmaceutical companies.

Basic Information

Product Name	Bistramide K
CAS No.	155660-92-7
Molecular Formula	C54H84N8O14
Molecular Weight	1045.3 g/mol
Synonyms	Bistramide K; Bistramide-K; Bistramide K (cyclic depsipeptide); Lissoclinotoxin A; Lissoclinotoxin A (cyclic depsipeptide); (3S,6R,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42S,45S,48S,51S)-45-[(2S)-butan-2-yl]-6,9,12,15,18,21,24,27,30,33,36,39,42,48,51-pentadecaazatricyclo[48.3.1.13,6]pentapentacontane-3,51-dione; Cyclic depsipeptide Bistramide K
EINECS	Contact for details

Quality Control

Our Bistramide K is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant quality guidelines for research chemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.