Description

Cryptophycin B is a potent macrocyclic depsipeptide natural product originally isolated from cyanobacteria of the genus *Nostoc*. This compound matters as a highly cytotoxic agent that serves as a critical reference standard and a valuable lead structure in oncology research and drug discovery. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel anti-cancer therapeutics and studying tubulin polymerization inhibition.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in the development of cytotoxic agents.
• Oncology Research: Serves as a potent biochemical tool for studying mechanisms of apoptosis, cell cycle arrest, and tubulin dynamics in cancer cell lines.
• Drug Discovery & Medicinal Chemistry: Acts as a lead compound and a structural template for the synthesis and evaluation of novel anti-mitotic analogs with improved therapeutic profiles.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) campaigns to identify new compounds with similar mechanisms of action or to validate assay systems.
• Academic & Preclinical Studies: Utilized in university and institutional labs for fundamental research into the biology of natural product toxins and their molecular targets.

Basic Information

Product Name	Cryptophycin B
CAS No.	155645-50-4
Molecular Formula	C43H58ClN3O8
Molecular Weight	804.39 g/mol
Synonyms	Cryptophycin B; (3S,6R,10S,13R,16S,19S,22R,26S,29S,32S,33R)-33-Chloro-26-ethyl-10,13,16,19,22-pentamethyl-3,6,29-tribenzyl-1,4,7,12,15,18,21,24,27,30-decaoxo-2,5,8,11,14,17,20,23,28,31-decaazatritriacontane-32-carboxylic acid; ARAST; LL-E33288 complex component gamma; Antibiotic LL-E33288 gamma; NSC 657679
EINECS	Contact for details

Quality Control

Our Cryptophycin B is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.