Description

2,6-Difluoronicotinaldehyde is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both aldehyde and fluorine substituents, makes it an essential precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoropyridine moiety enhances metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and organic electronic materials that require fluorinated aromatic units.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new fluorination chemistry and heterocycle formation.
• Custom Synthesis Building Block: Provides a handle for further functionalization (e.g., via reductive amination or condensation) in contract manufacturing and custom synthesis projects.

Basic Information

Product Name	2,6-Difluoronicotinaldehyde
CAS No.	155601-65-3
Molecular Formula	C6H3F2NO
Molecular Weight	143.09 g/mol
Synonyms	2,6-Difluoropyridine-3-carboxaldehyde; 3-Formyl-2,6-difluoropyridine; 2,6-Difluoro-3-pyridinecarboxaldehyde; Nicotinaldehyde, 2,6-difluoro-; 2,6-Difluoro-3-formylpyridine; Pyridine-3-carboxaldehyde, 2,6-difluoro-; 2,6-Difluoronicotinaldehyde (primary name)
EINECS	Contact for details

Quality Control

Our 2,6-Difluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and production. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.