Description

Pregnenolone-3-o-Methylthiophosphonate is a chemically modified derivative of the endogenous steroid hormone pregnenolone, designed for enhanced stability and specific reactivity. This compound is a valuable synthetic intermediate and research chemical, primarily utilized in the development of novel steroid-based pharmaceuticals and biochemical probes. It is of significant interest to researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroid-based drug candidates and therapeutic agents.
• Biochemical Research: Used as a precursor or probe in studying steroid hormone metabolism, receptor interactions, and enzyme inhibition.
• Fine Chemical Synthesis: Serves as a specialized intermediate for the preparation of complex, high-value steroid derivatives.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic Research: Utilized in university and institutional labs for exploratory chemistry and biological activity studies.

Basic Information

Product Name	Pregnenolone-3-o-Methylthiophosphonate
CAS No.	155538-87-7
Molecular Formula	C22H35O4PS
Molecular Weight	426.55 g/mol
Synonyms	Pregnenolone 3-Methylthiophosphonate; 3β-Hydroxy-5-pregnen-20-one 3-Methylthiophosphonate; (3β)-3-[(Methylsulfanyl)phosphonoxy]pregn-5-en-20-one; Pregnenolone Methyl Thiophosphate Ester; 5-Pregnen-3β-ol-20-one 3-Methylthiophosphonate; Pregnenolone O-Methyl Thiophosphonate; Pregnenolone 3-O-Methylthiophosphonate
EINECS	Contact for details

Quality Control

Our Pregnenolone-3-o-Methylthiophosphonate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.