Description

4'-Demethylamino-4',5'-Dihydroxystaurosporine is a chemically modified derivative of the potent protein kinase inhibitor staurosporine. This compound is of significant interest in biochemical and pharmacological research due to its altered selectivity profile and potential for enhanced biological activity. It is primarily utilized by research scientists and pharmaceutical developers in the fields of oncology, cell signaling, and drug discovery.

Application

• Biochemical Research: Used as a key reference standard and tool compound for studying protein kinase inhibition mechanisms.
• Oncology Research: Investigated for its potential anti-proliferative and pro-apoptotic effects on various cancer cell lines.
• Drug Discovery: Serves as a critical intermediate or lead compound in the development of novel kinase-targeted therapeutics.
• Cell Signaling Pathways: Employed to modulate and dissect complex intracellular signaling cascades in experimental models.
• Academic & Pharmaceutical R&D: Essential for high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4'-Demethylamino-4',5'-Dihydroxystaurosporine
CAS No.	155416-34-5
Molecular Formula	C27H24N4O4
Molecular Weight	468.51 g/mol
Synonyms	4'-Demethylamino-4',5'-dihydroxystaurosporine; 4'-Demethylamino-4',5'-dihydroxy-staurosporine; 4'-Demethylamino-4',5'-dihydroxy K-252a; 4'-Demethylamino-4',5'-dihydroxy K252a; 4'-Demethylamino-4',5'-dihydroxy K 252a; 4'-Demethylamino-4',5'-dihydroxy-K-252a; 4'-Demethylamino-4',5'-dihydroxy-K252a
EINECS	Contact for details

Quality Control

Our 4'-Demethylamino-4',5'-Dihydroxystaurosporine is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and structural confirmation. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.