Description

Zaragozic Acid D2 is a potent and selective inhibitor of squalene synthase, a key enzyme in the sterol biosynthesis pathway. This compound is a critical research tool for studying cholesterol metabolism and fungal ergosterol biosynthesis, offering significant value in biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disorders, antifungal drug discovery, and lipid biology.

Application

• Biochemical Research: Used as a specific inhibitor to study the mevalonate pathway and the role of squalene synthase in sterol synthesis.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery of novel cholesterol-lowering agents and antifungal drugs.
• Metabolic Disorder Studies: Applied in cellular and animal models to investigate dysregulated cholesterol homeostasis and related diseases.
• Enzyme Kinetics & Mechanism: Employed to characterize the inhibition kinetics and binding mechanisms of squalene synthase.
• Academic Research: A valuable tool in university laboratories for teaching and advanced research in biochemistry and medicinal chemistry.
• Reference Standard: Used for quality control, method development, and calibration in analytical laboratories.

Basic Information

Product Name	Zaragozic Acid D2
CAS No.	155179-15-0
Molecular Formula	C45H70O14
Molecular Weight	835.04 g/mol
Synonyms	Zaragozic Acid D; L-731,120; Squalestatin D2; Zaragozic Acid D (ZGA D); (1R,2S,5S,6S,7S,8S,9S)-8-[(2S,3S,4S,5S)-5-[(1S)-1-Carboxy-2-hydroxyethyl]-3,4-dihydroxyoxolan-2-yl]-2,5,6,7,8,9-hexahydroxy-3-oxatricyclo[4.2.1.0²,⁵]nonane-4,9-dicarboxylic acid; Squalene Synthase Inhibitor D2
EINECS	Contact for details

Quality Control

Our Zaragozic Acid D2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets high-purity research standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.