Description

Zaragozic Acid D CAS NO 155179-14-9 is a potent and selective inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical research tool for studying lipid metabolism, sterol biosynthesis, and related cellular processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in metabolic disease research and drug discovery.

Application

• Biochemical Research: Used as a specific inhibitor to study the mevalonate pathway and isoprenoid biosynthesis in cell culture and enzymatic assays.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery of novel cholesterol-lowering agents and antifungal drugs.
• Metabolic Disease Studies: Applied in research models to investigate atherosclerosis, hypercholesterolemia, and other disorders linked to dysregulated lipid metabolism.
• Enzyme Mechanism Studies: A valuable probe for elucidating the structure and function of squalene synthase and related enzymes.
• Academic Research: Employed in university and institutional labs for fundamental research in biochemistry, molecular biology, and chemical biology.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Zaragozic Acid D
CAS No.	155179-14-9
Molecular Formula	C₃₉H₆₂O₁₀
Molecular Weight	690.90 g/mol
Synonyms	Zaragozic Acid D; L-731,120; Squalestatin 1; Zaragozic Acid A1; (1R,2S,5S,6S,7S,8S,9S)-8-[(2S,3S,4S,5S)-3,4-Dihydroxy-5-[(1S)-1-hydroxyhexyl]oxolan-2-yl]-2,5,7,9-tetrahydroxy-3,6,8-trimethyl-1,4-dioxaspiro[4.5]decane-7-carboxylic Acid; Squalene Synthase Inhibitor L-731,120; FR 900098 (related analog)
EINECS	Contact for details

Quality Control

Our Zaragozic Acid D is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.