Description

Ac-Tyr-Val-Lys(Biotinyl)-Asp-2,6-Dimethylbenzoyloxymethylketone is a specialized, biotinylated peptide derivative designed as a potent and selective protease inhibitor. This compound matters for researchers and developers requiring high-precision tools to study and modulate specific enzymatic pathways in biological systems. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, proteomics, and biochemical assay development.

Application

• Protease Inhibition Studies: Acts as a key research tool for investigating the function and inhibition kinetics of specific serine or cysteine proteases.
• Drug Discovery & Development: Serves as a lead compound or a molecular probe in the design of novel therapeutic agents targeting protease-related diseases.
• Biochemical Assay Development: Used in the creation of high-throughput screening (HTS) assays to identify new enzyme inhibitors.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) to identify and characterize active enzymes in complex biological samples.
• Signal Pathway Analysis: Utilized to dissect and understand specific intracellular signaling cascades where the target protease plays a critical role.
• Affinity Purification: The biotin tag enables the use of streptavidin-based systems for the pull-down and isolation of target proteins or enzyme complexes.

Basic Information

Product Name	Ac-Tyr-Val-Lys(Biotinyl)-Asp-2,6-Dimethylbenzoyloxymethylketone
CAS No.	154719-25-2
Molecular Formula	C46H64N8O12S
Molecular Weight	953.11 g/mol
Synonyms	Ac-YVK(Biotin)-D-2,6-Dimethylbenzoyloxymethylketone; Biotinylated Peptide Inhibitor; Ac-Tyr-Val-Lys(Biotin)-Asp-2,6-Dimethylbenzoyloxymethyl Ketone; Protease Inhibitor 154719-25-2; Biotin-Ac-YVK(D-2,6-DMB)MK; Activity-Based Probe (ABP) with Biotin; N-Acetyl-L-tyrosyl-L-valyl-N6-(biotinyl)-L-lysyl-L-α-aspartyl 2,6-dimethylbenzoyloxymethyl ketone
EINECS	Contact for details

Quality Control

Our Ac-Tyr-Val-Lys(Biotinyl)-Asp-2,6-Dimethylbenzoyloxymethylketone is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.